Warning! //
Our risk assessment system is based on the latest scientific and medical knowledge available in the most respected scientific and medical journals.
Please keep in mind that the risk calculation does not cover other than genetic factors. Environmental factors such as smoking, diet, stress, and physical activity play an important role in the development of the disease. In case your risk is low it does not guarantee that you will not have the disease, or in case of high risk, not means you may certainly develop the disease.
CORONARY ARTERY
Coronary artery disease (CAD) is a group of diseases such as stable and unstable angina, myocardial infarction, and arteriosclerosis. CAD is the main cause of death and disability worldwide and represents a complex disease with both genetic and environmental determinants. CAD is a result of plaque buildup in a person’s arteries blocking blood flow that transports oxygen and vital nutrients necessary for the proper functioning of the heart. Heritability factors for CAD risk account for 30–60% of the interindividual variation. Prevention of CAD involves a combination of lifestyle factors and physiological parameters, often combined with medications. In the case of treatment, medications play a central role in reducing mortality in patients with CAD.
CAD risk factors: Older age / Gender (male) / Smoking / Diabetes status / Angina or heart attack in a 1st degree relative < 60 / Chronic kidney disease / Atrial fibrillation / Blood pressure treatment / Rheumatoid arthritis / HDL level / BMI.
ATRIAL FIBRILLATION
Atrial fibrillation (AF) is the most common cardiac arrhythmia, characterized by the absence of coordinated atrial contractions. In the case of AF, the heart rate rises to 180 beats (normal rate 60-80) per minute, lasting from seconds to days. Symptoms include shortness of breath and weakness. AF affects nearly 1% of the population, prevalence is 1.5 times higher among men. AF in the general population is heritable. For treatment, electrical cardioversion or anti-arrhythmic medications are used. If the medications are not working, catheter or surgical procedures are applied.
AF Risk factors: Older age / High blood pressure / Coronary heart disease / Heart failure / Rheumatic heart disease / Myocardial infarction / Heart valve defects / Pericarditis / Congenital heart defects / Hyperthyroidism, sleep apnea, metabolic syndrome, chronic kidney and lung diseases / Alcohol use / Obesity / Family history.
PERIPHERAL ARTERIAL
Peripheral arterial disease (PAD) occurs when plaque, formed from fat, cholesterol, calcium, fibrous tissue, and other substances in the blood, builds up in the walls of the arteries, causing problems with heart, brain, and other organs. To date, this disorder is often underdiagnosed, poorly understood, and much more common than was expected a few years ago. It is estimated that ca. 12% of the adult population worldwide has PAD and this disease affects men and women equally. PAD may be asymptomatic or have various symptoms such as rest pain, ischemic ulcers, gangrene, atypical leg pain. Studies have demonstrated 58% of the genetic heritability of PAD. There are several ways to treat PAD, such as smoking cessation, lipid-lowering therapy, hypertension management, and antithrombotic therapy.
PAD risk factors: Smoking / Older age / Diabetes / Hypertension / Hyperlipidemia / Obesity / Metabolic syndrome / Chronic kidney disease.
VENOUS THROMBOEMBOLISM
Venous thromboembolism (VTE) is a term defining deep vein thrombosis, pulmonary embolism, or both. VTE is characterized by blood clots in a vein, which can grow and dislocate. VTE is associated with morbidity and mortality. VTE affects 2% to 5% of the population. About 30% of surviving patients develop recurrent VTE within 10 years. The incidence of VTE differs by age, race, and gender, with a higher prevalence in white men aged 45-79. To date, anticoagulant therapy is the main treatment for symptoms, also helping reduce recurrent VTE risk. One major side effect is the increased risk of hemorrhage, which may be fatal in up to 25% of cases. For life-threatening situations, thrombolytics and surgical clot removal are used. Temporary inferior vein filters are used in patients with a high risk of deep vein thrombosis.
VTE risk factors: Family history / Surgery / Trauma / Chronic disease / Obesity / Pregnancy / Oral contraceptives / Hormone replacement therapy / Cancer Immobility / Dehydration / Smoking.
INTRACRANIAL ANEURYSM
Intracranial aneurysm (IA) is characterized by weakness in the wall of a cerebral artery causing ballooning of the blood vessels in the brain with devastating consequences. The incidence of IA is 5% to 10% worldwide and disease is 1.24-1.6 times more common in women than in men. Optimal treatment for IA takes into account both
physiological and individual factors, such as vessels' localization, size and morphology, presence of thrombus, age, medical history, family history, and the overall health of a patient. IA prevention must be applied in individuals with two or more affected first-degree relatives.
IA risk factors: Aging Gender (female) / Smoking / Hypertension / Atherosclerosis / Alcohol and drug abuse (cocaine) / Head injury / Estrogen deficiency in menopause / Arteriovenous malformation / Carotid artery stenosis / Autosomal dominant polycystic kidney disease / Marfan syndrome / Ehlers-Danlos syndrome / Neurofibromatosis / Family history.
WELLNESS//
The secret to living healthier, longer, and more athletic is on the Genetic Passport's Wellness test panel.! What is in our Genetic Passport Wellness test panel based on molecular DNA analysis of 68 gene regions?
GENETIC PREDISPOSITIONS
1) Immune System
2) Atrial fibrillation (AF)
3) Coronary artery disease (CAD)
4) Intracranial aneurysm (IA)
5) Peripheral arterial disease (PAD)
6) Venous thromboembolism (VTE)
7) Obesity
8) Type 1 diabetes
9) Type 2 diabetes
10) Hyperthyroidism
11) Folate Metabolism
12) Gluten Intolerance
13) Lactose Intolerance
14) Sugar Consumption
15) Alzheimer
16) Osteoporosis
17) Rheumatoid arthritis
18) Primary open-angle glaucoma (POAG)
19) Exfoliating glaucoma
20) Age-related macula degeneration (AMD)
21) Vitamine B12
22) Vitamine B6
23) Vitamine D
24) Sports Performance
REPORTING
●Determining the most common 24 genetic disease risks in the world in numerical rates.
●Comparing personal risks with population risks numerically.
●Separate disclosure of the measures required to reduce the genetic and environmental risk rates for each disease.
●Explanation of the trigger factors one by one according to the risk rate for each disease.
●Descriptive information of all environmental factors necessary to minimize or even eliminate risks by risk rate for each disease.
●Nutritional and exercise recommendations for each disease.
●Emergency response warning against high-risk rates.
●Assessing the possibility of increased risk after the interaction of other genetic regions despite the low risk of disease.
●Assessing the possibility of decreasing the risk after the interaction of other genetic regions despite the high risk of disease.
GENETIC PASSPORT® CHECK-UP //
INTRODUCING THE WORLD'S MOST ADVANCED DNA TEST.
Genetic Check-Up based on molecular DNA analysis of 150 gene regions. Genetic Passport determines the risks of nearly 40 genetic diseases, ranging from cancer to Alzheimer's, sports performance to obesity, and diabetes.
GENETIC PREDISPOSITIONS
1) Breast Cancer (BC)
2) Lung Cancer (LC)
3) Colorectal Cancer (CC)
4) Gastric Cancer (GC)
5) Basal Cell Carcinoma (BCC)
6) Bladder Cancer
7) Prostate Cancer (PC)
8) Melanoma
9) Atrial fibrillation (AF)
10) Coronary artery disease (CAD)
11) Intracranial aneurysm (IA)
12) Peripheral arterial disease (PAD)
13) Venous thromboembolism (VTE)
14) Obesity
15) Type 1 diabetes
16) Type 2 diabetes
17) High blood pressure
18) Hyperthyroidism
19) Folate Metabolism
20) Gluten Intolerance
21) Lactose Intolerance
22) Sugar Consumption
23) Alzheimer
24) Osteoporosis
25) Multiple Sclerosis (MS),
26) Migraine with Aura
27) Psoriasis
28) Rheumatoid arthritis
29) The systemic lupus erythematosus (SLE)
30) Primary open-angle glaucoma (POAG)
31) Exfoliating glaucoma
32) Age-related macula degeneration (AMD)
33) Vitamine B12
34) Vitamine B6
35) Vitamine D
36) ACTN'3 (R577X)
37) ACE (I/D)
ANALYZED GENE REGIONS
Alzheimer disease APOE
Alzheimer disease APOE
Atrial fibrillation 4q25
Atrial fibrillation PITX2
Basal cell carcinoma PADI6 rs7538XXX
Basal cell carcinoma Intergenic rs801XXX
Bladder cancer TACC3
Bladder cancer MYC
Breast cancer TP53
Breast cancer RAD51B
Breast cancer ATM rs1800XXX
Breast cancer ATM rs1800XXX
Breast cancer ATM rs1800XXX
Breast cancer ATM rs1801XXX
Breast cancer ATM rs3092XXX
Breast cancer ATM rs3218XXX
Breast cancer ATM rs3218XXX
Breast cancer TNRC9
Breast cancer BRCA1
Breast cancer ATM
Breast cancer BRCA1 rs80357XXX
Breast cancer BRCA2
Celiac disease HLA-DQA1
Celiac disease HLA-DRA
Celiac disease Intergenic rs4639XXX
Celiac disease Intergenic rs4713XXX
Celiac disease Intergenic rs7454XXX
Celiac disease HLA-DQB1
Colorectal cancer SMAD7
Colorectal cancer Intergenic rs4779XXX
Colorectal cancer SMAD7
Colorectal cancer Intergenic rs6983XXX
Colorectal cancer TCF7L2
Coronary artery disease LPA
Coronary artery disease CDKN2B-AS1
Coronary artery disease Intergenic rs10757XXX
Coronary artery disease CDKN2B-AS1 rs2383XXX
Coronary artery disease CDKN2B-AS1 rs2383XXX
Coronary artery disease LPA
Exfoliating glaucoma LOXL1
Exfoliating glaucoma LOXL1 rs3825XXX
Folate Metabolism MTHFR
Gallstone disease ABCG8 rs11887XXX
Gastric cancer MTHFR rs1801XXX
Graves' disease IL-23R rs10889XXX
Graves' disease TNF-α rs1800XXX
Graves' disease TNF-α rs1800XXX
Graves' disease IL-23R rs2201XXX
Graves' disease IL-23R rs7530XXX
Intracranial aneurysm SOX17 rs10958XXX
Intracranial aneurysm CDKN2A/CDKN2B
Lactose intolerance MCM6 rs4988XXX
Lung cancer CHRNA3 rs1051XXX
Lung cancer HYKK rs8034XXX
Lung cancer CHRNA5 rs951XXX
Male pattern baldness Intergenic
Male pattern baldness Intergenic rs6625XXX
Melanoma MC1R rs1805XXX
Migraine with aura MTHFR rs1801XXX
Multiple sclerosis ILR2A
Multiple sclerosis HLA-DRA
Multiple sclerosis IL7R rs6897XXX
Obesity MC4R
Obesity MC4R
Obesity APOA2
Obesity PCSK1
Obesity APOA5
Obesity SH2B1
Osteoporosis LRP5 rs3736228
Osteoporosis LRP5 rs4988321
Peripheral arterial disease CHRNA5
Primary open-angle glaucoma SIX1
Primary open-angle glaucoma ATOH7
Primary open-angle glaucoma CAV1-CAV2
Primary open-angle glaucoma TMCO1
Prostate cancer FUNDC2P2
Prostate cancer Intergenic rs16901XXX
Prostate cancer CASC17
Prostate cancer Intergenic
Psoriasis TNF-α
Psoriasis LCE3D
Rheumatoid arthritis TRAF1
Rheumatoid arthritis Intergenic rs6457617
Rheumatoid arthritis STAT4
Sugar consumption SLC2A2
Systemic lupus erythematosus STAT4
Systemic lupus erythematosus IRF5
Systemic lupus erythematosus ITGAM
Systemic lupus erythematosus TNF-a
Systemic lupus erythematosus HLA-DQA1
Systemic lupus erythematosus SKIV2L
Systemic lupus erythematosus STAT4
Systemic lupus erythematosus ITGAM
Type 1 diabetes PTPN22
Type 1 diabetes CLEC16A
Type 1 diabetes STAT4
Type 1 diabetes HLA-DQA1
Type 2 diabetes CDKN2B
Type 2 diabetes Intergenic
Type 2 diabetes TCF7L2
Type 2 diabetes SLC30A8
Type 2 diabetes PPARG
Type 2 diabetes TCF7L2
Type 2 diabetes Intergenic
Type 2 diabetes Intergenic
Type 2 diabetes FTO rs9939XXX
Venous thromboembolism F2 rs1799XXX
Venous thromboembolism F5
Vitamin B12 FUT2
Vitamin B6 ALPL
Vitamin D CYP2R1
Vitamin D CYP2R1
Vitamin D GC
Vitamin D GC
Muscle type ACTN3
Cardiyac capacity ACE
REPORTING
●Determining the most common 40 genetic disease risks in the world in numerical rates.
●Comparing personal risks with population risks numerically.
●Separate disclosure of the measures required to reduce the genetic and environmental risk rates for each disease.
●Explanation of the trigger factors one by one according to the risk rate for each disease.
●Descriptive information of all environmental factors necessary to minimize or even eliminate risks by risk rate for each disease.
●Nutritional and exercise recommendations for each disease.
●Emergency response warning against high-risk rates.
●Assessing the possibility of increased risk after the interaction of other genetic regions despite the low risk of disease.
●Assessing the possibility of decreasing the risk after the interaction of other genetic regions despite the high risk of disease.