Warning! //

Our risk assessment system is based on the latest scientific and medical knowledge available in the most respected scientific and medical journals.

Please keep in mind that the risk calculation does not cover other than genetic factors. Environmental factors such as smoking, diet, stress, and physical activity play an important role in the development of the disease. In case your risk is low it does not guarantee that you will not have the disease, or in case of high risk, not means you may certainly develop the disease.

CORONARY ARTERY

 

Coronary artery disease (CAD) is a group of diseases such as stable and unstable angina, myocardial infarction, and arteriosclerosis. CAD is the main cause of death and disability worldwide and represents a complex disease with both genetic and environmental determinants. CAD is a result of plaque buildup in a person’s arteries blocking blood flow that transports oxygen and vital nutrients necessary for the proper functioning of the heart. Heritability factors for CAD risk account for 30–60% of the interindividual variation. Prevention of CAD involves a combination of lifestyle factors and physiological parameters, often combined with medications. In the case of treatment, medications play a central role in reducing mortality in patients with CAD.
CAD risk factors: Older age / Gender (male) / Smoking / Diabetes status / Angina or heart attack in a 1st degree relative < 60 / Chronic kidney disease / Atrial fibrillation / Blood pressure treatment / Rheumatoid arthritis / HDL level / BMI.

 

ATRIAL FIBRILLATION

 

Atrial fibrillation (AF) is the most common cardiac arrhythmia, characterized by the absence of coordinated atrial contractions. In the case of AF, the heart rate rises to 180 beats (normal rate 60-80) per minute, lasting from seconds to days. Symptoms include shortness of breath and weakness. AF affects nearly 1% of the population, prevalence is 1.5 times higher among men. AF in the general population is heritable. For treatment, electrical cardioversion or anti-arrhythmic medications are used. If the medications are not working, catheter or surgical procedures are applied.
AF Risk factors: Older age / High blood pressure / Coronary heart disease / Heart failure / Rheumatic heart disease / Myocardial infarction / Heart valve defects / Pericarditis / Congenital heart defects / Hyperthyroidism, sleep apnea, metabolic syndrome, chronic kidney and lung diseases / Alcohol use / Obesity / Family history.

 

PERIPHERAL ARTERIAL

Peripheral arterial disease (PAD) occurs when plaque, formed from fat, cholesterol, calcium, fibrous tissue, and other substances in the blood, builds up in the walls of the arteries, causing problems with heart, brain, and other organs. To date, this disorder is often underdiagnosed, poorly understood, and much more common than was expected a few years ago. It is estimated that ca. 12% of the adult population worldwide has PAD and this disease affects men and women equally. PAD may be asymptomatic or have various symptoms such as rest pain, ischemic ulcers, gangrene, atypical leg pain. Studies have demonstrated 58% of the genetic heritability of PAD. There are several ways to treat PAD, such as smoking cessation, lipid-lowering therapy, hypertension management, and antithrombotic therapy.
PAD risk factors: Smoking / Older age / Diabetes / Hypertension / Hyperlipidemia / Obesity / Metabolic syndrome ​/ Chronic kidney disease.

VENOUS THROMBOEMBOLISM

 

Venous thromboembolism (VTE) is a term defining deep vein thrombosis, pulmonary embolism, or both. VTE is characterized by blood clots in a vein, which can grow and dislocate. VTE is associated with morbidity and mortality. VTE affects 2% to 5% of the population. About 30% of surviving patients develop recurrent VTE within 10 years. The incidence of VTE differs by age, race, and gender, with a higher prevalence in white men aged 45-79. To date, anticoagulant therapy is the main treatment for symptoms, also helping reduce recurrent VTE risk. One major side effect is the increased risk of hemorrhage, which may be fatal in up to 25% of cases. For life-threatening situations, thrombolytics and surgical clot removal are used. Temporary inferior vein filters are used in patients with a high risk of deep vein thrombosis.
VTE risk factors: Family history / Surgery / Trauma / Chronic disease / Obesity / Pregnancy / Oral contraceptives / Hormone replacement therapy / Cancer ​Immobility ​/ Dehydration ​/ Smoking.

 

INTRACRANIAL ANEURYSM​

Intracranial aneurysm (IA) is characterized by weakness in the wall of a cerebral artery causing ballooning of the blood vessels in the brain with devastating consequences. The incidence of IA is 5% to 10% worldwide and disease is 1.24-1.6 times more common in women than in men. Optimal treatment for IA takes into account both

physiological and individual factors, such as vessels' localization, size and morphology, presence of thrombus, age, medical history, family history, and the overall health of a patient. IA prevention must be applied in individuals with two or more affected first-degree relatives.
IA risk factors: Aging Gender (female) / Smoking / Hypertension / Atherosclerosis / Alcohol and drug abuse (cocaine) / Head injury / Estrogen deficiency in menopause ​/ Arteriovenous malformation ​/ Carotid artery stenosis / Autosomal dominant polycystic kidney disease / Marfan syndrome / Ehlers-Danlos syndrome / Neurofibromatosis ​/ Family history.

 

WELLNESS//

 

The secret to living healthier, longer, and more athletic is on the Genetic Passport's Wellness test panel.! What is in our Genetic Passport Wellness test panel based on molecular DNA analysis of 68 gene regions?

GENETIC PREDISPOSITIONS 

 

 1) Immune System

 2) Atrial fibrillation (AF)

 3) Coronary artery disease (CAD)

 4) Intracranial aneurysm (IA)

 5) Peripheral arterial disease (PAD)

 6) Venous thromboembolism (VTE)

 7) Obesity

 8) Type 1 diabetes

 9) Type 2 diabetes

10) Hyperthyroidism

11) Folate Metabolism

12) Gluten Intolerance

13) Lactose Intolerance

14) Sugar Consumption

15) Alzheimer

16) Osteoporosis

17) Rheumatoid arthritis

18) Primary open-angle glaucoma (POAG)

19) Exfoliating glaucoma

20) Age-related macula degeneration (AMD)

21) Vitamine B12 

22) Vitamine B6

23) Vitamine D

24) Sports Performance

REPORTING

 

 

●Determining the most common 24 genetic disease risks in the world in numerical rates.

 

●Comparing personal risks with population risks numerically.

 

●Separate disclosure of the measures required to reduce the genetic and environmental risk rates for each disease.

 

●Explanation of the trigger factors one by one according to the risk rate for each disease.

 

●Descriptive information of all environmental factors necessary to minimize or even eliminate risks by risk rate for each disease.

 

●Nutritional and exercise recommendations for each disease.

 

●Emergency response warning against high-risk rates.

 

●Assessing the possibility of increased risk after the interaction of other genetic regions despite the low risk of disease.

 

●Assessing the possibility of decreasing the risk after the interaction of other genetic regions despite the high risk of disease.

GENETIC PASSPORT® CHECK-UP //

 

INTRODUCING THE WORLD'S MOST ADVANCED DNA TEST.

Genetic Check-Up based on molecular DNA analysis of 150 gene regions. Genetic Passport determines the risks of nearly 40 genetic diseases, ranging from cancer to Alzheimer's, sports performance to obesity, and diabetes.

GENETIC PREDISPOSITIONS

1) Breast Cancer (BC)

2) Lung Cancer (LC)

3) Colorectal Cancer (CC)

4) Gastric Cancer (GC)

5) Basal Cell Carcinoma (BCC)

6) Bladder Cancer

7) Prostate Cancer (PC)

8) Melanoma

9) Atrial fibrillation (AF)

10) Coronary artery disease (CAD)

11) Intracranial aneurysm (IA)

12) Peripheral arterial disease (PAD)

13) Venous thromboembolism (VTE)

14) Obesity

15) Type 1 diabetes

16) Type 2 diabetes

17) High blood pressure

18) Hyperthyroidism

19) Folate Metabolism

20) Gluten Intolerance

21) Lactose Intolerance

22) Sugar Consumption

23) Alzheimer

24) Osteoporosis

25) Multiple Sclerosis (MS),

26) Migraine with Aura

27) Psoriasis

28) Rheumatoid arthritis

29) The systemic lupus erythematosus (SLE)

30) Primary open-angle glaucoma (POAG)

31) Exfoliating glaucoma

32) Age-related macula degeneration (AMD)

33) Vitamine B12 

34) Vitamine B6

35) Vitamine D

36) ACTN'3 (R577X)

37) ACE (I/D) 

ANALYZED GENE REGIONS

 

Alzheimer disease APOE 
Alzheimer disease APOE 
Atrial fibrillation 4q25 
Atrial fibrillation PITX2 
Basal cell carcinoma PADI6  rs7538XXX 
Basal cell carcinoma Intergenic  rs801XXX 
Bladder cancer TACC3 
Bladder cancer MYC
Breast cancer TP53 
Breast cancer RAD51B 
Breast cancer ATM rs1800XXX
Breast cancer ATM rs1800XXX 
Breast cancer ATM rs1800XXX 
Breast cancer ATM rs1801XXX 
Breast cancer ATM rs3092XXX 
Breast cancer ATM rs3218XXX
Breast cancer ATM rs3218XXX 
Breast cancer TNRC9 
Breast cancer BRCA1 

Breast cancer ATM  
Breast cancer BRCA1 rs80357XXX 
Breast cancer BRCA2 
Celiac disease HLA-DQA1  
Celiac disease HLA-DRA  
Celiac disease Intergenic rs4639XXX
Celiac disease Intergenic rs4713XXX
Celiac disease Intergenic rs7454XXX 
Celiac disease HLA-DQB1  
Colorectal cancer SMAD7 
Colorectal cancer Intergenic rs4779XXX 
Colorectal cancer SMAD7 
Colorectal cancer Intergenic rs6983XXX 
Colorectal cancer TCF7L2 
Coronary artery disease LPA 
Coronary artery disease CDKN2B-AS1 
Coronary artery disease Intergenic rs10757XXX 
Coronary artery disease CDKN2B-AS1 rs2383XXX
Coronary artery disease CDKN2B-AS1 rs2383XXX 
Coronary artery disease LPA 
Exfoliating glaucoma LOXL1 

Exfoliating glaucoma LOXL1 rs3825XXX 
Folate Metabolism MTHFR 
Gallstone disease ABCG8 rs11887XXX 
Gastric cancer MTHFR rs1801XXX 
Graves' disease IL-23R rs10889XXX
Graves' disease TNF-α rs1800XXX
Graves' disease TNF-α rs1800XXX
Graves' disease IL-23R rs2201XXX 
Graves' disease IL-23R rs7530XXX 
Intracranial aneurysm SOX17 rs10958XXX 
Intracranial aneurysm CDKN2A/CDKN2B 
Lactose intolerance MCM6 rs4988XXX 
Lung cancer CHRNA3 rs1051XXX 
Lung cancer HYKK rs8034XXX 
Lung cancer CHRNA5 rs951XXX 
Male pattern baldness Intergenic  
Male pattern baldness Intergenic rs6625XXX  
Melanoma MC1R rs1805XXX
Migraine with aura MTHFR rs1801XXX 
Multiple sclerosis ILR2A
Multiple sclerosis HLA-DRA

Multiple sclerosis IL7R rs6897XXX
Obesity MC4R
Obesity MC4R 
Obesity APOA2 
Obesity PCSK1
Obesity APOA5 
Obesity SH2B1 
Osteoporosis LRP5 rs3736228
Osteoporosis LRP5 rs4988321 
Peripheral arterial disease CHRNA5
Primary open-angle glaucoma SIX1 
Primary open-angle glaucoma ATOH7
Primary open-angle glaucoma CAV1-CAV2  
Primary open-angle glaucoma TMCO1 
Prostate cancer FUNDC2P2 
Prostate cancer Intergenic rs16901XXX
Prostate cancer CASC17 
Prostate cancer Intergenic
Psoriasis TNF-α 
Psoriasis LCE3D 

Rheumatoid arthritis TRAF1 
Rheumatoid arthritis Intergenic rs6457617 
Rheumatoid arthritis STAT4 
Sugar consumption SLC2A2 
Systemic lupus erythematosus STAT4 
Systemic lupus erythematosus IRF5 
Systemic lupus erythematosus ITGAM  
Systemic lupus erythematosus TNF-a  
Systemic lupus erythematosus HLA-DQA1 
Systemic lupus erythematosus SKIV2L  
Systemic lupus erythematosus STAT4 
Systemic lupus erythematosus ITGAM 
Type 1 diabetes PTPN22 
Type 1 diabetes CLEC16A 
Type 1 diabetes STAT4 
Type 1 diabetes HLA-DQA1 
Type 2 diabetes CDKN2B 
Type 2 diabetes Intergenic 
Type 2 diabetes TCF7L2 
Type 2 diabetes SLC30A8 
Type 2 diabetes PPARG

Type 2 diabetes TCF7L2 
Type 2 diabetes Intergenic 
Type 2 diabetes Intergenic 
Type 2 diabetes FTO rs9939XXX 
Venous thromboembolism F2 rs1799XXX
Venous thromboembolism F5
Vitamin B12 FUT2 
Vitamin B6 ALPL 
Vitamin D CYP2R1 
Vitamin D CYP2R1 
Vitamin D GC 
Vitamin D GC 

Muscle type ACTN3 

Cardiyac capacity ACE 

REPORTING

 

 

●Determining the most common 40 genetic disease risks in the world in numerical rates.

 

●Comparing personal risks with population risks numerically.

 

●Separate disclosure of the measures required to reduce the genetic and environmental risk rates for each disease.

 

●Explanation of the trigger factors one by one according to the risk rate for each disease.

 

●Descriptive information of all environmental factors necessary to minimize or even eliminate risks by risk rate for each disease.

 

●Nutritional and exercise recommendations for each disease.

 

●Emergency response warning against high-risk rates.

 

●Assessing the possibility of increased risk after the interaction of other genetic regions despite the low risk of disease.

 

●Assessing the possibility of decreasing the risk after the interaction of other genetic regions despite the high risk of disease.

© COPYRIGHT 2020 GENETIC PASSPORT